Planer-Friedrich, B; Kerl, C; Colina Blanco, A; Clemens, S: Dimethylated thioarsenates - a potentially dangerous blind spot in current worldwide regulatory limits for arsenic in rice., Journal of Agricultural and Food Chemistry, American Chemical Society (2022), doi:10.1021/acs.jafc.2c02425
Arsenic (As) occurrence in rice is a serious human health threat. Worldwide, regulations typically limit only carcinogenic inorganic As, but not possibly carcinogenic dimethylated oxyarsenate (DMA). However, there is emerging evidence that “DMA”, determined by routine acid-based extraction and analysis, hides a substantial share of dimethylated thioarsenates that have similar or higher cytotoxicities than arsenite. Risk assessments characterizing the in vivo toxicity of rice-derived dimethylated thioarsenates are urgently needed. In the meantime, either more sophisticated methods based on enzymatic extraction and separation of dimethylated oxy- and thioarsenates have to become mandatory or total As should be regulated.

last modified 2022-12-01